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There will be a first start of the season while fringe players Arda Guler, Brahim Diaz and Dani Ceballos are all in contention for starting berths.
Madrid were handed an injury scare on Friday and the midfielder is unlikely to be risked this weekend.
The visitors head into Saturday’s game with a mountain of injuries with many players sustaining long-term issues.
Cadiz are set to be without Jose Mari, Rominigue Kouame, Luis Hernandez, Federico San Emeterio and Jorge Mare this weekend. Aiham Ousou is a doubt with a knock.
Cadiz are scrapping for their lives at the bottom, while Madrid will be heavily rotated for Saturday’s game as they coast to the title.
Ancelotti’s squad is laden with quality and there will be a few players with points to prove. The hosts have lost one La Liga game all season and, while this will be far from a classic, Madrid should cruise to three points.
Cadiz predicted lineup vs Real Madrid
Cadiz predicted lineup vs Real Madrid (4-4-2): Ledesma; Carcelen, Hernandez, Chust, Pires; Alejo, Alex, Alcaraz, Navarro; Juanmi, Gomez.