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The Seagulls’ injury woes this season have undoubtedly limited their capacity to build on a stellar 2022/23 season.
De Zerbi will once again be without a whole host of stars for Chelsea’s visit. Kaoru Mitoma, Evan Ferguson, Solly March, Pervis Estupinan, Jack Hinselwood and James Milner are all set to miss out on Wednesday.
Joao Pedro is a doubt with an ankle injury, while Jan Paul van Hecke is struggling with a hamstring problem.
Reece James had a huge impact off the bench at the City Ground and could be included in the starting XI on Wednesday.
Pochettino could also welcome Christopher Nkunku back into the lineup with the Frenchman appearing off the bench in recent outings.
Chelsea will arrive on the south coast in high spirits having fought from behind at the weekend and there’s a real sense of the Blues gathering some crucial end-of-season momentum which could have a role to play at the start of 2024/25.
Brighton have earned some respite in their previous two games and are generally tougher to beat on home soil, but their injury woes are significant and they could struggle to contain a Chelsea side that’s found its groove from an attacking sense.
The return of Reece James will only aid the visitors and they should win again on Wednesday night.