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Pep Guardiola’s side are seeking a fourth consecutive crown and control their own destiny with four games left in their season.
Guardiola will be well aware of the threat that the visitors pose, though, particularly after a 1-0 defeat at Molineux earlier in the season.
Wolves will not have Gary O’Neil on the touchline, though, with the manager serving a ban for his conduct following the 2-1 defeat to West Ham.
Manchester City had feared that Ederson may miss the rest of the season after suffering a shoulder injury against Nottingham Forest, but Pep Guardiola allayed concerns over the goalkeeper on Friday, and he may well be fit to start. Phil Foden and Ruben Dias could return after illness.
Tommy Doyle, who will join Wolves permanently at the end of the seaosn, is for now ineligible to face his parent club but Santiago Bueno, Jean-Ricner Bellegarde and Pedro Neto have returned to training and might feature.
Predicted line-ups
Manchester City XI: Ederson; Walker, Stones, Dias, Gvardiol; Rodri; Silva, De Bruyne, Foden, Grealish; Haaland.
Wolves XI: Sa; Semedo, Kilman, Toti; Doherty, Lemina, Gomes, Traore, Ait-Nouri; Cunha, Hwang.