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Fresh from playing out a thrilling 3-3 draw with Real Madrid in the Champions League on Tuesday, Man City must turn their attention back to the Premier League against Luton on Saturday.
With both Liverpool and Arsenal playing on Sunday, City have the chance to put the pressure on in the title race and can go top with victory.
But visitors Luton, despite a lengthy injury list, can be expected to put up a fight as they continue their battle against relegation.
Team news
Kyle Walker and Nathan Ake are still out for the Citizens, although goalkeeper Ederson is reportedly close to a return.
Pep Guardiola is expected to make changes with this match sandwiched between the two legs of their Champions League tie with Real Madrid.
Luton are in the midst of an injury crisis, with defenders Gabriel Osho, Amari’i Bell, Issa Kabore, Mads Andersen and Dan Potts all unavailable.
Also on the sidelines are Marvelous Nakamba, Elijah Adebayo, Chiedozie Ogbene and Jacob Brown.
Man City are unbeaten in 16 home games in the Premier League this season, having won 11 and drawn five.
They have also scored 71 goals in 31 league matches, giving them an average of 2.29 goals per game.
Luton, meanwhile, have won only two league games on their travels, leaking 38 goals in 16 road fixtures.